AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor.[1] It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University.

AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2.[4] The 4-methyl functional analog MAM-2201 probably has similar affinities.[original research?] AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors.[5] AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.

Changes in legislation have affected supply routes of new psychoactive substances such as synthetic cannabinoids with evidence of supply over the darknet. We identified darknet drug markets using an index database and Tor Browser to access markets. We identified SC in product listings using a custom-programmed script. We collected data at bimonthly intervals (August 2016–April 2017). Eleven darknet markets listed SC for sale, the largest number from China, UK, US, Netherlands, and Germany. Formulations available were high purity powder/crystal, smoking preparations and vape preparations. The top five listed compounds from China across the time points were FUB-AMB, ABD-FUBINACA, 5F-NPB-22, MAB-CHMINACA, and NM-2201. 5F-CUMYL-4CN-PINACA was unavailable at early time points but emerged during the study. Cost of high purity formulations from China ranged from 1.3 to 3.1 Euro per gram for quantities ≥1000 g. Europe and North America accounted for 99% smoking preparations predominantly in small packages (<50 g). SC are widely available on the darknet with availability changing over time. High purity formulations are predominantly available from China in quantities up to kilograms with price per gram reducing with increased quantity. Small packages of ready-made smoking mixtures are available from Europe and North America. contact us

Showing 1–12 of 33 results