Description

AM-1235 (1-(5-fluoropentyl)-3-(naphthalen-1-oyl)-6-nitroindole) is a drug that acts as a potent and reasonably selective agonist for the cannabinoid receptor CB₁.

Pharmacodynamics

AM-1235 is a cannabinoid receptor agonist with K_i of 1.5 nM at CB₁ compared to 20.4 nM at CB₂.^[1] While the 6-nitro substitution on the indole ring reduces affinity for both CB₁ and CB₂ relative to the unsubstituted parent compound AM-2201, CB₂ affinity is reduced much more, resulting in a CB₁ selectivity of around 13 times.^[2] This is in contrast to other related compounds such as AM-1221 where a 6-nitro substitution instead confers significant selectivity for CB₂.^[3] 

AM-1235. Buy AM6545 ONLINE

• Molecular FormulaC₂₄H₂₁FN₂O₃
• Average mass404.434 Da
• Monoisotopic mass404.153625 Da
• ChemSpider ID26633899

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