Description

AM-1241 (1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole) is a chemical from the aminoalkylindole family that acts as a potent and selective agonist for the cannabinoid receptor CB₂,^[1][2] with a K_i of 3.4 nM at CB₂ and 80 times selectivity over the related CB₁ receptor.^[3][4] It has analgesic effects in animal studies, particularly against “atypical” pain such as hyperalgesia and allodynia.^[5] This is thought to be mediated through CB₂-mediated peripheral release of endogeous opioid peptides,^[6] as well as direct activation of the TRPA1 channel.^[7] It has also shown efficacy in the treatment of amyotrophic lateral sclerosis in animal models.^[8][9]

AM-1241

• Molecular Formula C₂₂H₂₂IN₃O₃
• Average mass 503.333 Da
• Monoisotopic mass 503.070587 Da
• ChemSpider ID 8317404

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