AM-1241

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Description

AM-1241 (1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole) is a chemical from the aminoalkylindole family that acts as a potent and selective agonist for the cannabinoid receptor CB2,[1][2] with a Ki of 3.4 nM at CB2 and 80 times selectivity over the related CB1 receptor.[3][4] It has analgesic effects in animal studies, particularly against “atypical” pain such as hyperalgesia and allodynia.[5] This is thought to be mediated through CB2-mediated peripheral release of endogeous opioid peptides,[6] as well as direct activation of the TRPA1 channel.[7] It has also shown efficacy in the treatment of amyotrophic lateral sclerosis in animal models.[8][9]

ChemSpider 2D Image | AM-1241 | C22H22IN3O3

AM-1241

  • Molecular Formula C22H22IN3O3
  • Average mass 503.333 Da
  • Monoisotopic mass 503.070587 Da
  • ChemSpider ID 8317404

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Additional information

Weight (Grams)

25 Grams, 50 Grams, 100 Grams, 500 Grams, 1000 Grams