Description

AM-411 (part of the AM cannabinoid series) is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk.

AM-411 is a potent and fairly selective CB₁ full agonist with a K_i of 6.80 nM, but is still also a moderately potent CB₂ agonist with a K_i of 52.0 nM.^[1] It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis

(6aR,10aR)-3-(Adamantan-1-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

• Molecular Formula C₂₆H₃₄O₂
• Average mass 378.547 Da
• Monoisotopic mass 378.255890 Da
• ChemSpider ID
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