Description

JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors, with a K_i of 11 nM at CB₁ and 33 nM at CB₂. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2′-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands.^[2] Other 2′-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.^[3][4]

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JWH-250

• Molecular FormulaC₂₂H₂₅NO₂
• Average mass335.439 Da
• Monoisotopic mass335.188538 Da
• ChemSpider ID23256117
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