3,4-Methyl​enedioxy​methamphetamine (MDMA),[note 1] commonly known as ecstasy (E), is a psychoactive drug primarily used as a recreational drug.[13] The desired effects include altered sensations and increased energy, empathy, and pleasure.[13][14] When taken by mouth, effects begin after 30–45 minutes and last 3–6 hours.[11][15]

Adverse effects include addiction, memory problems, paranoia, difficulty sleeping, teeth grinding, blurred vision, sweating, and a rapid heartbeat.[14] Deaths have been reported due to increased body temperature and dehydration.[14] Following use people often feel depressed and tired.[14] MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine, and noradrenaline in parts of the brain.[14][15] It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.[6][16]

MDMA is illegal in most countries[14][17] and, as of 2018, has no approved medical uses.[6][18] Limited exceptions are sometimes made for research.[15] Researchers are investigating whether MDMA may assist in treating severe, treatment-resistant posttraumatic stress disorder (PTSD) with phase 3 clinical trials to look at effectiveness and safety expected to begin in 2018.[19] In 2017 the FDA granted MDMA a breakthrough therapy designation[note 2] for PTSD, meaning if studies show promise, a review for potential medical use could occur more quickly.[23]

MDMA was first developed in 1912 by Merck.[24] It was used to improve psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s.[14][15] MDMA is commonly associated with dance parties, raves, and electronic dance music.[25] It is often sold mixed with other substances such as ephedrine, amphetamine, and methamphetamine.[14] In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population).[26] This was broadly similar to the percentage of people who use cocaine or amphetamines, but fewer than for cannabis or opioids.[26] In the United States, as of 2017, about 7% of people have used MDMA at some point in their life and 0.9% have used in the last year

ChemSpider 2D Image | MDMA | C11H15NO2


  • Molecular Formula C11H15NO2
  • Average mass 193.242 Da
  • Monoisotopic mass 193.110275 Da
  • ChemSpider ID 1556
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