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Methadone is an opioid medication used as a pain reliever and as part of drug addiction detoxification and maintenance programs. It is available only from a certified pharmacy.

Methadone reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the “high” associated with the drug addiction.

What to know before taking Methadone

You should not use methadone if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.

Methadone can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Adult dose for Methadone

Individualize dose; dosing recommendations should only be considered as suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient; this drug has a narrow therapeutic index, especially when combined with other drugs; monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy.

Parenteral:
Initiation in Opioid Non-Tolerant Patients:
Initial dose: 2.5 mg to 10 mg IV every 8 to 12 hours
Maintenance dose: Slowly titrate to effect; more frequent administration may be required to maintain adequate analgesia during initiation, however, extreme caution is necessary to avoid overdosing.

Comments:
-May be administered IV, IM or subcutaneously, although the absorption of IM or subcutaneous injections has not been well studied and appears to be unpredictable; local tissue reactions may occur.
-Oral methadone is not indicated as an as-needed analgesic; due to increased risk of overdose and death with this long-acting opioid, its use is limited to chronic pain management.

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