Methylphenidate

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Description

Methylphenidate, sold under the trade name Ritalin among others, is a stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.[2] It is a first line medication for ADHD.[2] It may be taken by mouth or applied to the skin.[2] Different formulations have varying durations of effect.[2]

Common side effects include trouble sleeping, anxiety and weight loss.[2] More serious side effects may include psychosis, allergic reactions, prolonged erections, abuse and heart problems. [2] Methylphenidate is believed to work by improving the action of catecholamines in the brain.[5] It achieves this by blocking dopamine and norepinephrine reuptake by neurons.[5][6] Methylphenidate is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes.[2][7]

Methylphenidate was first made in 1944 and was approved for medical use in the United States in 1955.[2][8] It was originally sold by CIBA, now Novartis Corporation.[8] It is estimated that in 2013, 2.4 billion doses of methylphenidate were taken worldwide.[9] About 80% of this was taken by people in the United States making it the 47th most prescribed medication there.[9][10] It is available as a generic medication.[2] In the United States, the wholesale cost of the immediate release formulation is less than US$0.30 per dose as of 2018.[11]

ChemSpider 2D Image | Methylphenidate | C14H19NO2

Methylphenidate

  • Molecular Formula C14H19NO2
  • Average mass 233.306 Da
  • Monoisotopic mass 233.141586 Da
  • ChemSpider ID 4015

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Additional information

Weight (Grams)

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